Who we are

The Center for Cancer Evolution (CCE) was founded in 2016 by Drs. Michor, Pellman, and Polyak at the Dana-Farber Cancer Institute.

The CCE focuses on understanding cancer evolution through a multi-disciplinary approach. Our goal is to understand the mechanisms behind tumor evolution, metastasis formation, emergence of drug resistance to ultimately provide more specialized and effective patient care in a variety of different cancer types.


SIApopr: a computational method to simulate evolutionary branching trees for analysis of tumor clonal evolution. Bioinformatics, 2017

SIApopr (Simulating Infinite-Allele populations) is an R package to simulate time-homogeneous and inhomogeneous stochastic branching processes under a very flexible set of assumptions using the speed of C ++. The software simulates clonal evolution with the emergence of driver and passenger mutations under the infinite-allele assumption. The software is an application of the Gillespie Stochastic Simulation Algorithm expanded to a large number of cell types and scenarios, with the intention of allowing users to easily modify existing models or create their own.